1-Boc Piperazine: A Versatile Intermediate in Medicinal Chemistry

Introduction
1-Boc Piperazine is a widely used chemical intermediate in pharmaceutical research, known for its role in the synthesis of a wide variety of bioactive molecules. The compound features a piperazine ring protected by a Boc (tert-butoxycarbonyl) group, which enhances its stability and selectivity in multi-step synthetic procedures.

Chemical Identity
IUPAC Name: 1-(tert-Butoxycarbonyl)piperazine
CAS Number: 57260-71-6
Molecular Formula: C9H18N2O2
Molecular Weight: 186.25 g/mol
Appearance: White to off-white crystalline powder
Solubility: Soluble in common organic solvents such as dichloromethane, methanol, and acetonitrile

Structural Features
1-Boc Piperazine consists of a six-membered piperazine ring, where one nitrogen is protected with a tert-butoxycarbonyl (Boc) group. This protection:

Enhances the selective functionalization of the second nitrogen
Provides stability under basic conditions
Is easily removed under acidic conditions, making it ideal for stepwise synthesis

Applications of 1-Boc Piperazine
1. Pharmaceutical Intermediate
It is a key building block in the synthesis of several classes of drugs, including:

Antipsychotics
Antidepressants
Anti-inflammatory agents
Anti-cancer compounds
The Boc group allows for temporary protection during multi-step synthesis, enabling the development of diverse heterocyclic scaffolds.

2. Medicinal Chemistry and Drug Discovery
1-Boc Piperazine is commonly used in combinatorial chemistry and lead optimization, offering:

Increased lipophilicity
Improved pharmacokinetic properties
Potential for receptor binding enhancement
3. Custom Peptidomimetic Synthesis
In the design of peptidomimetics, 1-Boc Piperazine serves as a flexible spacer or scaffold that mimics peptide bonds, useful in:

Enzyme inhibitors
Signal transduction mimics
Receptor ligands

Handling and Safety
Hazards: May cause skin or eye irritation
Precautions: Handle with gloves and eye protection; avoid inhalation or prolonged exposure
Storage Conditions: Store in a tightly sealed container, in a cool, dry place away from acids

Packaging and Supply
Available in:

Small Packs: 5g, 25g, 100g for research use
Bulk Quantities: 1kg, 5kg, and custom volumes for commercial production
Supplied with COA, MSDS, and global shipping options.

Conclusion
1-Boc Piperazine is a cornerstone intermediate in the field of organic and medicinal chemistry. Its versatility, ease of use, and clean deprotection make it a preferred choice for researchers and manufacturers developing advanced drug candidates and custom molecules.

Need bulk or custom-packed 1-Boc Piperazine? Contact us for quotations, technical documentation, and application support tailored to your R&D or production goals.

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At Martino McCabe, we believe that every individual—regardless of age or health status—deserves to live with dignity, respect, and safety. Sadly, some of the most vulnerable members of our community—our elders—often fall victim to abuse and neglect in the very places entrusted with their care. As leading Jacksonville Nursing Home Abuse Attorneys, we are relentless in our mission to protect victims and hold negligent facilities accountable.

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Premises liability is a legal concept that holds property owners responsible for maintaining safe conditions. Whether it’s a slippery floor, poor lighting, broken handrails, or hazardous walkways, property owners have a duty to address dangers or warn visitors about potential risks. When they fail in this duty, and someone is injured as a result, a Jacksonville Premises Liability Attorney can help recover compensation for the victim.

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