Introduction
4-tert-Butylthiophenol is a specialized aromatic thiol widely used in organic synthesis, materials science, and surface modification. This compound is known for its unique sulfur functionality combined with a sterically hindered tert-butyl group, making it a versatile reagent and intermediate in chemical industries.

Chemical Identity
Chemical Name: 4-tert-Butylbenzenethiol
Synonyms: p-tert-Butylthiophenol, 4-(tert-Butyl)thiophenol
Molecular Formula: C10H14S
Molecular Weight: 166.28 g/mol
CAS Number: 98-29-3
Appearance: Colorless to pale yellow liquid with a distinct thiol odor
Solubility: Insoluble in water; soluble in organic solvents like ethanol, diethyl ether, and benzene

Structure and Reactivity
The compound contains:

A thiol (-SH) group at the para-position of a benzene ring
A tert-butyl group (-C(CH₃)₃) that provides steric bulk and hydrophobicity
This structure makes 4-tert-butylthiophenol an excellent nucleophile, especially in reactions where selective functionalization of surfaces or molecules is desired.

Applications of 4-tert-Butylthiophenol
1. Ligand in Metal Coordination Chemistry
The thiol group readily binds to transition metals such as gold, silver, and copper, making it a key component in:

Self-Assembled Monolayers (SAMs) on gold surfaces
Design of metal-organic frameworks (MOFs)
Catalytic systems where sulfur-metal interactions are crucial
2. Surface Functionalization and Nanotechnology
4-tert-Butylthiophenol is commonly used to modify the surface properties of metals, especially:

Gold nanoparticles and electrodes for sensor applications
Corrosion-resistant coatings
Functional thin films for electronic and biomedical devices
The tert-butyl group provides hydrophobicity and steric control, making it suitable for engineering surface wettability and reactivity.

3. Organic Synthesis Intermediate
It serves as a valuable intermediate in the synthesis of:

Pharmaceutical compounds
Polymers
Agrochemicals
Functional aromatic sulfides and sulfoxides
Its reactivity enables formation of C–S bonds via substitution and oxidation reactions, useful for tailoring molecular frameworks.

4. Precursor for Disulfide and Thioether Synthesis
Through controlled oxidation or alkylation, 4-tert-butylthiophenol can be converted into:

Disulfides (R–S–S–R)
Thioethers (R–S–R’)
Sulfonic acids or sulfoxides for medicinal and polymer chemistry

Handling and Safety
Toxicity: Harmful if inhaled or ingested; can cause irritation to skin and eyes
Odor: Strong thiol odor; use in well-ventilated area or fume hood
Storage: Keep in a cool, dry, and tightly closed container away from oxidizers
Protective Equipment: Gloves, lab coat, safety goggles, and appropriate respiratory protection
Refer to the Material Safety Data Sheet (MSDS) for detailed handling instructions.

Packaging and Availability
4-tert-Butylthiophenol is available in:

Analytical & research grades (1g, 5g, 25g)
Industrial-scale quantities (100g, 1kg, 5kg)
Custom purity specifications upon request
Supplied with COA, MSDS, and TDS. Custom packaging for moisture-sensitive or air-sensitive use available.

Conclusion
4-tert-Butylthiophenol is a high-value aromatic thiol with applications ranging from nanotechnology and catalysis to drug synthesis and surface chemistry. Its reactivity, stability, and tunable properties make it a preferred choice for chemists and material scientists.

✅ Summary:
Strong metal-binding thiol group
Excellent for gold surface modification
Precursor to disulfides, thioethers, and sulfonic acids
Widely used in materials science and organic synthesis
Available in both research and industrial grades

0

Introduction
6-Bromo-2-naphthol is a halogenated aromatic compound derived from naphthol, featuring a bromine atom at the 6-position and a hydroxyl group at the 2-position of the naphthalene ring. Due to its reactivity and structural versatility, it finds wide usage in pharmaceutical research, dye manufacturing, and fine chemical synthesis.

Chemical Identity
IUPAC Name: 6-Bromo-2-naphthol
Molecular Formula: C10H7BrO
Molecular Weight: 223.07 g/mol
CAS Number: 116057-18-6
Appearance: Pale yellow to off-white crystalline powder
Solubility: Slightly soluble in water, soluble in organic solvents such as ethanol, chloroform, and ether

Structural Features
Naphthalene Core: Provides aromatic stability and electron-rich characteristics
Hydroxyl Group (-OH): Increases polarity and allows for hydrogen bonding
Bromo Substituent (-Br): Enables further electrophilic substitution or cross-coupling reactions
These features make 6-Bromo-2-naphthol a useful starting material or intermediate in complex syntheses.

Applications of 6-Bromo-2-naphthol
1. Pharmaceutical Intermediate
Used in the synthesis of naphthol-based therapeutic agents and bioactive heterocycles with potential antimicrobial and anticancer activity.

2. Dye and Pigment Industry
Acts as a precursor for azo dyes, reactive dyes, and other chromophores used in textiles and coatings.

3. Organic Synthesis
Useful in Suzuki, Heck, and Sonogashira coupling reactions, allowing extension and functionalization of the aromatic framework.

4. Analytical Chemistry
Sometimes employed as a reagent or derivatization agent in spectrophotometric analysis.

Safety and Handling
Hazards: May cause skin and eye irritation; harmful if swallowed or inhaled
Precautions: Use gloves, goggles, and appropriate protective clothing; operate in a fume hood
Storage: Store in a cool, dry, and well-ventilated place, away from heat and oxidizing agents

Packaging and Availability
Available in:

Laboratory Quantities: 1g, 5g, 25g
Bulk Quantities: 100g, 500g, 1kg, 5kg packs
Supplied with COA, MSDS, and compliance documentation on request.

Conclusion
6-Bromo-2-naphthol is a valuable compound for researchers and industries working in the areas of drug development, organic dye chemistry, and fine chemical synthesis. Its functional groups make it ideal for a wide range of synthetic applications.

Need bulk or custom-packed 6-Bromo-2-naphthol? Contact us for specifications, pricing, and delivery information tailored to your R&D or manufacturing requirements.

 

0

Introduction
1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide Hydrochloride (EDC HCl) is a widely used water-soluble carbodiimide reagent employed in peptide synthesis, protein conjugation, and organic transformations. Known for its efficiency and compatibility with aqueous environments, EDC HCl plays a crucial role in amide bond formation, especially in zero-length crosslinking reactions.

 

Chemical Identity
Chemical Name: 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide Hydrochloride
Abbreviation: EDC HCl
Molecular Formula: C8H17N3·HCl
Molecular Weight: 191.70 g/mol
CAS Number: 25952-53-8
Appearance: White to off-white crystalline powder
Solubility: Highly soluble in water and polar organic solvents (DMF, DMSO)

Key Applications of EDC HCl
1. Peptide Synthesis
EDC HCl is extensively used to form amide bonds between carboxyl and amine groups in peptide coupling, particularly in solution-phase and solid-phase synthesis.

2. Protein and Antibody Crosslinking
Acts as a zero-length crosslinker in bioconjugation, enabling direct coupling of proteins or peptides to other biomolecules or surfaces.

3. DNA and RNA Labeling
EDC HCl activates carboxyl-modified oligonucleotides, allowing for labeling and immobilization on various matrices.

4. Biomaterials Functionalization
Widely used to modify surfaces of hydrogels, nanoparticles, and polymer scaffolds by coupling bioactive ligands or peptides.

5. Carboxyl Activation in Organic Chemistry
Ideal for coupling reactions in the synthesis of esters, amides, and other carboxylic acid derivatives.

Advantages of EDC HCl
Water-soluble and compatible with biological systems
Produces minimal by-products (urea derivatives)
Efficient at neutral to slightly acidic pH (4.5–7.5)
Does not introduce spacer atoms (zero-length)
Stable and easy to handle under ambient conditions

Handling and Storage
Store in a cool, dry place, away from moisture
Use with gloves and eye protection in a fume hood
Avoid prolonged exposure to air or moisture to maintain stability
Dispose of waste following local chemical safety guidelines

Packaging and Availability
Available in multiple pack sizes:

Laboratory Scale: 1g, 5g, 10g, 25g
Bulk Supply: 100g, 500g, 1kg, 5kg, 25kg fiber drums
Each batch is accompanied by a Certificate of Analysis (COA) and Material Safety Data Sheet (MSDS).

Conclusion
EDC HCl is a high-efficiency coupling reagent used in both research and industrial applications. Its versatility in bioconjugation, peptide synthesis, and surface modification makes it an indispensable tool in life sciences, biotechnology, and pharmaceutical development.

Looking to source EDC HCl in India, Italy, or globally? Contact us for bulk quotes, documentation, and reliable logistics support tailored to your needs.

 

0

0

Introduction
1-Boc Piperazine is a widely used chemical intermediate in pharmaceutical research, known for its role in the synthesis of a wide variety of bioactive molecules. The compound features a piperazine ring protected by a Boc (tert-butoxycarbonyl) group, which enhances its stability and selectivity in multi-step synthetic procedures.

Chemical Identity
IUPAC Name: 1-(tert-Butoxycarbonyl)piperazine
CAS Number: 57260-71-6
Molecular Formula: C9H18N2O2
Molecular Weight: 186.25 g/mol
Appearance: White to off-white crystalline powder
Solubility: Soluble in common organic solvents such as dichloromethane, methanol, and acetonitrile

Structural Features
1-Boc Piperazine consists of a six-membered piperazine ring, where one nitrogen is protected with a tert-butoxycarbonyl (Boc) group. This protection:

Enhances the selective functionalization of the second nitrogen
Provides stability under basic conditions
Is easily removed under acidic conditions, making it ideal for stepwise synthesis

Applications of 1-Boc Piperazine
1. Pharmaceutical Intermediate
It is a key building block in the synthesis of several classes of drugs, including:

Antipsychotics
Antidepressants
Anti-inflammatory agents
Anti-cancer compounds
The Boc group allows for temporary protection during multi-step synthesis, enabling the development of diverse heterocyclic scaffolds.

2. Medicinal Chemistry and Drug Discovery
1-Boc Piperazine is commonly used in combinatorial chemistry and lead optimization, offering:

Increased lipophilicity
Improved pharmacokinetic properties
Potential for receptor binding enhancement
3. Custom Peptidomimetic Synthesis
In the design of peptidomimetics, 1-Boc Piperazine serves as a flexible spacer or scaffold that mimics peptide bonds, useful in:

Enzyme inhibitors
Signal transduction mimics
Receptor ligands

Handling and Safety
Hazards: May cause skin or eye irritation
Precautions: Handle with gloves and eye protection; avoid inhalation or prolonged exposure
Storage Conditions: Store in a tightly sealed container, in a cool, dry place away from acids

Packaging and Supply
Available in:

Small Packs: 5g, 25g, 100g for research use
Bulk Quantities: 1kg, 5kg, and custom volumes for commercial production
Supplied with COA, MSDS, and global shipping options.

Conclusion
1-Boc Piperazine is a cornerstone intermediate in the field of organic and medicinal chemistry. Its versatility, ease of use, and clean deprotection make it a preferred choice for researchers and manufacturers developing advanced drug candidates and custom molecules.

Need bulk or custom-packed 1-Boc Piperazine? Contact us for quotations, technical documentation, and application support tailored to your R&D or production goals.

0